Strategic and Technology Challenges in Bioprocessing

For the production of nucleic acids, the pharmaceutical industry uses predominantly E. coli as a production host [9], represented also in the rising number of filed patents for pDNA production using E. coli over the last decade [29].Aside from nucleic acid production, E. coli is also used for the production of non-glycosylated proteins, where besides different hormones [30] especially antibody.. Process intensification aims to increase productivity in biologics manufacturing. Significant progress has been made in academia, the biopharmaceutical industry, and by the regulatory guidance since the 2000s. Process intensification can include all unit operations of a drug substance manufacturing process. The applied upstream concepts have.

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Scheme of an exemplary bioprocess development chain. This scheme… Download Scientific Diagram

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Our results provide the basis for future research on integrated process development considering interdependencies between USP and DSP; however, individual products need to be considered specifically. These interdependencies need to be understood for rational decision-making and efficient process development in research and industry.. Nowadays, the development of bioprocesses is an essential part of a large number of chemical, food, and pharmaceutical industries. The main purpose of the course “Introduction to Industrial Bioprocess Development” is to provide an overview of the common stages involved in this type of processes. The course is primarily aimed at students.