The main cause of abnormal Bence-Jones protein levels in your urine is a type of cancer called multiple myeloma. This cancer affects your blood cells and forms tumors inside your bones. This.. Urine analysis for Bence-Jones protein (BJP) has been a test for detection of free light chains (FLC) in the urine for over a century. The method, however, is not standardised. Urine from the same patient is sometimes concentrated by 10-50 fold and sometimes not prior to analysis.
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Bence Jones protein refers to a urinary protein that leaves the solution at approximately 56^oC under particular conditions of ionic strength and pH and returns to the solution on further heating to 100^oC. It represents a homogeneous population of kappa or lambda-type light chains. The presence of these immunoglobulin light-chain proteins in the urine is linked to several systemic diseases.. Urine protein dipsticks do not detect Bence Jones protein. Abnormal serum free light chain ratio is almost always present in association with the presence of Bence Jones in the urine. SNOMED-CT ID: 443363008: LOINC: 55899-9: Reference:



